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Paper based self-powered sensor patch could help diabetics measure glucose during exercise

One-time use paper-base sensors attaches directly to skin wicks sweat to a reservoir where chemical energy is converted to electrical energy, and monitors glucose without external power and sophisticated readout instruments

Binghampton - New self-powered paper patch could help diabetics measure glucose during exercise

18 Sep 2017 | Editor

A new paper-based sensor patch developed by researchers at Binghamton University, State University of New York could allow diabetics to effectively measure glucose levels during exercise.

Professor Seokheun Choi and fellow researchers have developed and demonstrated a self-powered, wearable and disposable patch that allows for non-invasive monitoring of glucose in human sweat. This wearable, single-use biosensor integrates a vertically stacked, paper-based glucose/oxygen enzymatic fuel cell into a standard BAND-AID adhesive patch.

According to the Researchers today’s most widespread methods for glucose self-testing involve monitoring glucose levels in blood. Conventional measurements, however, are not suitable for preventing hypoglycemia during exercise.

Three reasons conventional measurements are not suitable for hypoglycemia during exercise:

  1. the underlying process relies on invasive and inconvenient blood sampling, causing the possibility of sample contamination and skin irritation with sweat containing various electrolytes and proteins
  2. the method needs patients to carry many accessories during physical activity, including lancets, alcohol swabs and a relatively large glucometer
  3. the technique requires a sophisticated electrochemical sensing technique and sufficient electrical energy, which makes the technique difficult to be fully integrated in a compact and portable fashion
Binghampton University - Paper based glucose sensor powered by sweat

Figure: Binghampton University - Paper based glucose sensor powered by sweat

The researchers added that sweat-based glucose sensing is attractive for managing exercise-induced hypoglycemia because the measurement is performed during or immediately after exercise when there is enough sweat to obtain an adequate sample.

This potential alleviates shortcomings of conventional non-invasive sweat sensors, which can be hampered by the difficulty of collecting enough sweat for analysis, sample evaporation and the relatively long time required for sample collection.

"The paper-based device attaches directly to skin, wicks sweat to a reservoir where chemical energy is converted to electrical energy, and monitors glucose without external power and sophisticated readout instruments"

“The sensing platform holds considerable promise for efficient diabetes management, and a fully integrated system with a simple readout can be realized toward continuous non-invasive glucose monitoring,” wrote the researchers.

Professor Seokheun Choi, Binghamton University Electrical and Computer Science

A Single-Use, Self-Powered, Paper-Based Sensor Patch for Detection of Exercise-Induced Hypoglycemia

Eunyoung Cho | Maedeh Mohammadifar | Seokheun Choi

Received: 27 July 2017 | Revised: 23 August 2017 | Accepted: 27 August 2017 | Published: 31 August 2017

dx.doi.org/10.3390/mi8090265

Abstract

We report a paper-based self-powered sensor patch for prevention and management of exercise-induced hypoglycemia. The article describes the fabrication, in vitro, and in vivo characterization of the sensor for glucose monitoring in human sweat. This wearable, non-invasive, single-use biosensor integrates a vertically stacked, paper-based glucose/oxygen enzymatic fuel cell into a standard Band-Aid adhesive patch. The paper-based device attaches directly to skin, wicks sweat by using capillary forces to a reservoir where chemical energy is converted to electrical energy, and monitors glucose without external power and sophisticated readout instruments. The device utilizes (1) a 3-D paper-based fuel cell configuration, (2) an electrically conducting microfluidic reservoir for a high anode surface area and efficient mass transfer, and (3) a direct electron transfer between glucose oxidase and anodes for enhanced electron discharge properties. The developed sensor shows a high linearity of current at 0.02–1.0 mg/mL glucose centration (R2 = 0.989) with a high sensitivity of 1.35 µA/mM.

www.binghamton.edu   

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