Saturday, 20 Jan 2018

Applied Nanodetectors and CPI to develop a needle-free "breathalyser" for daily diabetes testing

Applied Nanodetectors is developing a simple breathalyser that will give diabetics a non invasive method for monitoring their daily glucose levels

13 Jan 2016 | Editor

Applied Nanodetectors Ltd is working together with the Centre for Process Innovation (CPI) to focus on the feasibility of designing and printing a novel low cost glucose sensor to be incorporated into a breathalyser to measure the levels of volatile organic compounds (VOC’s) in human breath. The ability to print glucose sensors provides the opportunity to mass produce the sensors at extremely low costs per unit.

The collaboration is part of a recent nine month Innovate UK project titled "Plasense" which finished in December 2015 and developed a low cost and scalable printed sensor technology onto flexible plastic substrates.

Further development work will look at upscaling the sensor and integration into a point of care diagnostic device. The project is a key breakthrough for the monitoring of glycemic levels and if commercialised, the technology could revolutionise the way in which we monitor glucose levels across the globe.

CPI/Applied Nanodetectors - Microfabricated sensors on plastic

Figure: CPI/Applied Nanodetectors - Microfabricated sensors on plastic

Diabetes is one of the biggest health challenges in the world today and despite many advances in disease treatment, the prevalence of diabetes is increasing dramatically. Improvements are required in the management of the disease, both for the healthcare provider and the patient.

Glucose monitoring is an essential requirement of disease management, however, effective and routine monitoring remains a constant challenge, primarily because of the invasive nature of glucose monitoring devices. Taking a blood sample remains an unpleasant experience and one of the main causes of poor patient compliance. This is particular acute for young sufferers, for whom daily blood tests are perhaps most traumatic.

A non-invasive handheld breath test device would significantly improve patient monitoring and self management, however current devices are yet to meet a price point that facilitates adoption to the mass market.

James Johnstone, Business Manager at CPI, said, "Applied Nanodetectors Ltd is a pioneering company and we are delighted to be working with them in this important step to take their innovative technology closer to market. The project evaluated the suitability of a range of gases for monitoring VOC’s and benchmarked their performance against existing technology. We were also able to optimise sensor performance. The incorporation of a low cost, printed glucose sensor offers great potential for the commercialisation of a multi-use and environmentally friendly breathalyser device for daily diabetic management. Regular self monitoring would lead to more effective patient treatment, a reduction in healthcare costs and a shift to more proactive point-of-care treatments."
Dr Victor Higgs, Managing Director at Applied Nanodetectors, said, "This project was an important step in the development of a low cost sensor platform for use as a breath test for the management of diabetes. This would provide diabetics with a non-invasive easy to use test compared to the established finger prick method. This new sensor platform offers both high sensitivity and industry leading reliability and can be modified for use in new clinical applications. Using the sensors in a portable handheld device will facilitate the creation of new point-of-care diagnostic tests, which will enable more efficient healthcare delivery leading to improved patient outcomes. Working with CPI has helped to accelerate the sensor development cycle and utilise plastic electronics technologies to obtain the most cost effective manufacturing solution."

www.uk-cpi.com    www.applied-nanodetectors.com   

About Centre for Process Innovation (CPI)

The Centre for Process Innovation is a UK-based technology innovation centre and part of the High Value Manufacturing Catapult. We use applied knowledge in science and engineering combined with state of the art development facilities to enable our partners to develop, prove, prototype and scale up the next generation of products and processes.

Our open innovation model enables clients to develop products and prove processes with minimal risk. We provide assets and expertise so our customers can demonstrate the process before investing substantial amounts of money in capital equipment and training. New products and processes can be shown to be feasible; on paper, in the lab and in the plant before being manufactured at an industrial scale.

By utilising our proven assets and expertise companies can take their products and processes to market faster. There is no down time in production as all of the process development is completed offsite and our technology transfer and engineering teams can help companies to transfer the product or process into full scale production at speed.

Source: Centre for Process Innovation (CPI)

About Applied Nanodetectors

Applied Nanodetectors was formed in 2004 and is a leading developer and supplier of nanosensor based solutions for environmental, healthcare and medical worldwide markets. We create new sensor based solutions to lead in these chosen markets and we will leverage our sensor array platform by collaborating with industry leaders to create value added products in their prospective markets. We will inspire our partners to create new innovative solutions that meet their customer needs.

Source: Applied Nanodetectors


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